Collection: C. elegans Physiology Assays
Caenorhabditis elegans serves as a valuable model organism for investigating fundamental physiological processes such as lipid metabolism, fecundity, and feeding behavior. These studies offer insights into conserved biological mechanisms relevant to human health.
Lipid Metabolism
C. elegans has been instrumental in elucidating the genetic and environmental factors
influencing lipid storage and utilization. Over 70% of its lipid metabolism-related genes are homologous to those in mammals, making it a pertinent model for studying fat regulation. Research utilizing C. elegans has shed light on the complex mechanisms of fat regulation in humans, facilitating the discovery of genes and compounds that modulate lipid metabolism.
Fecundity
The reproductive capacity of C. elegans, characterized by its rapid life cycle and prolific
offspring production, makes it an excellent model for studying fecundity. Investigations into the genetic and environmental factors affecting C. elegans reproduction have provided insights into fertility regulation, reproductive aging, and the impact of metabolic states on reproductive health.
Pharyngeal Pumping
Pharyngeal pumping in C. elegans, the rhythmic contraction of the pharynx for feeding, serves as a model for understanding neuromuscular function and feeding behaviors. The simplicity of its nervous system allows for detailed studies on how neural circuits control muscle activity. Research in this area has implications for understanding human neuromuscular diseases and feeding disorders. Additionally, pharyngeal pumping rates can reflect the organism's metabolic state, providing insights into how energy balance influences feeding behavior.
